American Journal of Kidney Diseases
04/08/2002
By Mark Greener
Overhydration lowers albumin levels among patients undergoing peritoneal dialysis, thereby offering a new therapeutic option.
Serum albumin levels predict mortality among patients with end-stage renal failure. However, the basis of the association between serum albumin levels and mortality is not well characterised. Some studies suggest a role for inflammation, while others propose a relationship with hydration. Moreover, no management strategy is proven to raise serum albumin levels in patients undergoing dialysis.
Researchers from York District Hospital and other British centres designed a study to determine if increasing ultrafiltration volume, thus decreasing dry weight, would increase serum albumin in this patient population. They enrolled 15 subjects undergoing continuous ambulatory peritoneal dialysis and six patients treated with continuous cycled peritoneal dialysis. The patients were assessed at base line and after four weeks. Between these times, clinicians increased the average daily ultrafiltrate volume from 1.00 to 1.29 L.
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