Men who have depression refractory to usual antidepressants may benefit from testosterone gel, according to the results of a randomized, placebo-controlled trial reported in the January issue of the American Journal of Psychiatry.
“Testosterone supplementation may produce antidepressant effects in men, but until recently it has required cumbersome parenteral administration,” write Harrison G. Pope, Jr., MD, and colleagues from McLean Hospital in Belmont, Massachusetts.
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