Bladder tumors that arise in patients exposed to high levels of arsenic demonstrate greater chromosomal instability than those that develop in patients exposed to lower levels, according to a report published in the November 20th issue of the Journal of the National Cancer Institute.
Given that the number of chromosomal alterations was directly related to tumor stage and grade, the findings suggest that arsenic exposure may be a risk factor for more aggressive bladder cancers, study author Dr. Lee E. Moore, from the National Cancer Institute, in Bethesda, Maryland, and colleagues note.
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