Using cannabis increases the risk of developing psychosis in psychosis-free subjects, according to a report in the August 15th issue of the American Journal of Epidemiology. Those with an established vulnerability to psychotic disorders are especially sensitive to the effects of the drug, resulting in a poor prognosis.
Dr. Jim van Os, of Maastricht University, the Netherlands, and colleagues report on a 3-year follow-up of 4045 psychosis-free subjects and 59 subjects with a baseline diagnosis of psychotic disorder. They assessed substance use at baseline, 1 year, and 3 years.
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