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Gender Can Influence Regional Brain Activity In Depressed Adults

By Elda Hauschildt

Regional brain activity in adults with a history of childhood-onset depression is influenced by both gender and variability in clinical course.

 North American researchers, led by Dr. Anita Miller, say the findings could have implications for investigating brain correlates of mood disorder and could help researchers develop more refined phenotypes.

 The investigators started with the hypothesis that electroencephalogram (EEG) asymmetry scores are associated with patient vulnerability to negative mood states and depression. Gender and clinical history variables were studied in 110 young adults.

 Of these, 55 patients had a documented clinical history of childhood-onset depression.   The 55 comparison subjects had no history of major psychopathology.      EEG measures of asymmetrical alpha frequency suppression were examined along with EEG patterns in relation to operational diagnoses of mental disorders in both childhood and adulthood.

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