Nefazodone improves sleep during the early stages of treatment in patients with moderate to severe depression, in comparison with paroxetine.
University of Bristol researchers from the England report the effects are seen within the first two weeks of therapy. Response then diminishes.
They point out that the effects of antidepressants on sleep are clinically important. It is known that selective serotonin reuptake inhibitors disturb sleep and 5-hydroxytryptamine receptor-blocking compounds can enhance the quality of sleep.
Investigators randomised 40 depression patients to either paroxetine (20 milligrams to 40 mg per day) or nefazodone (400 mg to 600 mg per day) for eight weeks. Objective and subjective quality of sleep and depression measures throughout the trial period.
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