Even though PNU-142633 is the most selective serotonin-1D (5-HT-1D) receptor agonist reported to date, it does not relieve migraine headache0–in contrast to triptan drugs, which are nonselective 5-HT-1B/1D receptor agonists.
Scientists at Pharmacia Corporation in Kalamazoo and at Pfizer Global Research and Development in Ann Arbor, Michigan developed PNU-142533, an isochroman aryl piperazine analogue, while investigating agents with antipsychotic potential.
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