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Simvastatin Protects against Endothelial Dysfunction in Type 2 Diabetes

Simvastatin minimises oxidative stress and endothelial dysfunction brought on by the cumulative effects of postprandial hypertriglyceridaemia and hyperglycaemia seen in type 2 diabetics.

The findings were presented here September 4th at the 38th annual meeting of the European Association for the Study of Diabetes (EASD). According to the researchers, from University of Udine, Azienda Ospedaliera S. Maria della Misericordia, and Morpurgo-Hofman Research Laboratory on Aging, all in Udine, Italy, postprandial hypertriglyceridaemia and hyperglycaemia are considered risk factors for cardiovascular disease and may induce endothelial dysfunction.

 However, their distinct role remains to be determined. In an effort to investigate the effects of simvastatin on endothelial function, the researchers enrolled 30 type 2 diabetic patients and 20 healthy individuals to treatment with either simvastatin 40 mg/day or placebo. Immediately before starting treatment; three to six days after; and 12 weeks after beginning treatment, patients were given three different meals: 1) a high-fat meal; 2) 75 g glucose alone; 3) a high-fat meal plus glucose.

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