The consistently higher persistence associated with the use of angiotensin II antagonists may help improve the management of blood pressure in patients with hypertension.
One of the most challenging problems in the care of patients with high blood pressure is patient noncompliance with antihypertensive therapy.
A large, retrospective study led by M. A. Marentette took a look at how well patient-compliance with antihypertensive therapy persists in routine clinical settings in Saskatchewan, Canada. The study retrospectively reviewed persistence of medication compliance among more than 46,000 patients managed by Saskatchewan Health from 1994 through 1998, who received at least one prescription for antihypertensive medication, but none in the 12 months prior to that prescription.
The prescriptions were classified as either angiotensin II antagonists, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, calcium channel blockers, or diuretics. Persistence of patient compliance with antihypertensive therapy was divided into four intervals, 180, 360, 540, and 720 days.
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