In patients with juvenile idiopathic arthritis (JIA), final height may depend upon the severity of growth retardation during the active phase of the disease and on catch-up growth after the discontinuation of prednisone, French researchers report.
Dr. Dominique Simon from H pital Robert Debr , Paris, and colleagues measured the height of 24 children with JIA, mean 3.5 years of age at the start of therapy. Height was expressed as the height standard deviation score for chronological age (HSDS/CA). The researchers compared the patient’s final height with reference values for the French population and to target height. Patients were followed for a mean of 13.6 years.
The team found that the combination of the disease and prednisone therapy result in shorter than predicted stature. During the active phase of the disease when patients were receiving prednisone, there was a mean loss of HSDS/CA of 2.7, which was associated with the length of time patients remained on prednisone (p<0.01).
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