05/03/2002
By Elda Hauschildt
Modafinil, a newly released, central stimulant used to treat narcolepsy, could help relieve spasticity in children with cerebral palsy.
Research was initiated after one patient was reported to have a dramatic reduction in spasticity when prescribed the drug, report investigators from the Texas Tech University Health Sciences Centre in Lubbock, United States.
A pilot project with 10 paediatric patients to attempted to confirm or refute modafinil's effect in cerebral palsy. "Modafinil appears to benefit spastic cerebral palsy by a yet to be determined mechanism," the researchers concluded.
They hypothesize that a primary effect of modafinil on brainstem structures reduces spasticity of central origin.
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