The purpose of this study was to determine changes in intramyocellular lipid (IMCL) content in the vastus lateralis of non-diabetic, physically-fit males over 72-hours fasting. Six men, mean age 35 years (range 23-55 years), BMI 23.7 kg.m(-2) (21.2-27.4 kg.m(-2)) undertook a water-only fast for 84 hours.
Vastus lateralis IMCL content was determined using proton magnetic-resonance spectroscopy ((1)H MRS) after 12- and 84-hours fasting. Venous blood was sampled at twelve-hour intervals throughout the fast. IMCL-(CH2)n/water and IMCL-(CH2)n/total creatine ratios increased from 0.00623 +/- 0.00065 to 0.0142 +/- 0.0015 (mean +/- S.E., p = 0.002) and 6.82 +/- 0.87 to 14.96 +/- 1.73 (p = 0.001) respectively.
Plasma FFA, serum triglyceride and whole-blood 3-hydroxybutyrate concentrations increased (p < 0.001, 0.05, 0.03 respectively), whilst plasma glucose and serum insulin concentrations decreased (both p < 0.001) during fasting. In conclusion, 72-hours water-only fasting produces a large increase in plasma FFA concentration, a drop in serum insulin concentration and accumulation of IMCL in the vastus lateralis muscle of non-diabetic, physically-fit men.
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