NEW YORK (Reuters Health) Jun 19 –
Mouse studies indicate that cyclooxygenase-2 (COX-2) is needed for bone repair, researchers report in the June issue of The Journal of Clinical Investigation.
Senior author Dr. Regis J. O’Keefe told Reuters Health that “during fracture healing, stem cells around the area of the broken bone need to differentiate, or turn into bone cells. Our studies show that the enzyme COX-2, which is inhibited by nonsteroidal antiinflammatory drugs and the coxibs, is necessary for this process of bone cell differentiation.”
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