Researchers from the Hospital General Vall d’Hebron, Barcelona, Spain, enrolled 36 patients with diabetes and proliferative diabetic retinopathy, and 28 patients without diabetes, who all underwent vitrectomy. The subjects were matched for age, sex and serum levels of free IGF-1.
The patients with diabetes and proliferative diabetic retinopathy showed raised levels of free IGF-1 in the vitreous fluid compared to those patients without diabetes
The authors concluded that the increased intravitreous levels of free IGF-1 in patients with proliferative diabetic retinopathy reflect diffusion from serum.
Clinical Science 2003;104:223-230
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