Losartan inhibits the increased leukocyte entrapment usually seen in the retinal microcirculation of diabetic rats, according to results of a study in Japan. This finding implies that the potent AT1 angiotensin II receptor antagonist may inhibit the development of diabetic retinopathy, the researchers maintain.
It is theorized that increased retinal leukocyte entrapment in diabetes may be associated with vascular nonperfusion and vascular leaking, thus leading to diabetic retinopathy, explain Dr. Fumihiko Mori and associates of the Asahikawa Medical College.
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