Among patients undergoing surgery for nasolacrimal duct obstruction, only those with a positive history for systemic disease or an abnormal-appearing lacrimal sac during surgery should undergo lacrimal sac biopsy.
Italian and American researchers made the recommendation on the basis of histopathologic reports for 302 specimens from 258 patients who had undergone routine dacrocystorhinostomy for nasolacrimal duct obstruction.
Medical records for those patients were mined for the following variables: age, gender, presenting symptoms, history of predisposing conditions, lacrimal system abnormalities before surgery, dye disappearance test, dacrocystogram or dacroscintillogram, and appearance of the lacrimal sac during surgery.
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