Expression of telomerase reverse transcriptase (hTERT) in cancer cells seems to depend on the gene being in a more open chromatin state than it is in normal cells, British and Swiss researchers have found.
Blocking this process could be a very effective therapeutic strategy. “Our results show that the telomerase gene is tightly coiled up in normal cells,” said lead researcher Professor Robert Newbold, from Brunel University. “But in cancer cells it exists in a much less compact form making it more accessible.”
Researchers from Brunel University north of London and the Swiss Cancer Research Institute found that hTERT in tumor cells was more sensitive to nuclease cleavage than hTERT in normal fibroblasts, particularly in the second intron
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