Oral vaccination of mice with recombinant Listeria monocytogenes expressing a human papillomavirus (HPV) oncogene elicits a specific immune response that prevents or reverses tumor growth, researchers in Taiwan report.
Dr. Show-Li Chen, of the National Defense Medical Center in Taipei, and colleagues constructed recombinant L. monocytogenes expressing E7, a tumor antigen that is consistently expressed in high-grade cervical dysplasias and cancers. A previous murine study had demonstrated the feasibility of this technique, but the vaccine had been administered intraperitoneally.
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