05/28/2002 By David Loshak
Vitamin C may inhibit collagen-induced platelet aggregation.
This may add to the protection that vitamin C is already known to give against coronary heart disease.
Researchers at the University of Freiburg, Germany, pointed out that epidemiological studies had shown that regular intake of vitamin C and vitamin E protected against oxidation in coronary heart disease.
The researchers also noted that cigarette smoke contained many free radicals and reactive oxygen-derived substances that enhanced platelet aggregation. This led them to investigate the effect of vitamin C as an antioxidant in plasma on platelet aggregation in both smokers and non-smokers.
The researchers recruited 40 volunteers, with an average age of 28 years, divided equally between chronic smokers (defined as having been smoking for an average of 21 “pack-years”) and non-smokers.
In each group, the volunteers were randomised to receive 3.0 mg. intravenous infusions of vitamin C or placebo consisting of 100 ml 0.9 percent saline solution.
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