Two particular polymorphisms in the osteoprotegerin gene promoter may be involved in the regulation of bone mineral density (BMD) and be a risk factor for osteoporosis in postmenopausal women, researchers report.
Dr. Janja Marc from the Clinical Center, Ljubljana, Slovenia, and colleagues screened 103 postmenopausal women with osteoporosis.
The researchers looked for sequence variations in the osteoprotegerin gene promoter and examined the association of these variations with BMD. Single-stranded conformation polymorphism analysis and DNA sequencing found four nucleotide substitutions: 209 G-A, 245 T-G, 889 C-T and 950 T-C, the researches note.
תגובות רוצה להצטרף לדיון?
יש להתחבר כדי להגיב.
התחבראין תגובות עדיין. היה הראשון להגיב!