התמחויות

Autologous Blood Cell Transplant Holds Promise in SLE

Laurie Barclay, MD


June 7, 2002 —

Autologous blood stem cell transplantation may have potential for effectively curing systemic lupus erythematosus (SLE), according to a single case report in the June issue of Arthritis & Rheumatism.

Following a course of immunosuppressive therapy with transplant of CD34+ cells, a woman with severe pulmonary impairment refractory to medication has been free of all medications for 21 months, with restored pulmonary and renal function.

“For patients with severe forms of autoimmunity, including SLE, purging autoreactive T cells from the immune repertoire by transplanting autologous hematopoietic stem cells is a therapeutic option,” write M. Brunner, MD, and colleagues from the University of Vienna in Austria. Despite aggressive treatment with steroids, azathioprine, cyclophosphamide, and immunopheresis over a four-year period, this 18-year-old woman had multisystem involvement with SLE and required repeated mechanical ventilation for lupus pneumonitis. After conditioning with cyclophosphamide and antithymocyte globulin, she received an infusion of 8.87 x 106 purified CD34+ cells per kg of body weight.

She had fever and septicemia during treatment and a subsequent episode of herpes zoster.


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