The extent of serum aminotransferase elevations and the degree of hepatocellular necrosis and inflammation seen on liver biopsy are the best predictors of fibrosis progression in patients with chronic hepatitis C, according to a report in the January issue of Gastroenterology.
“Fibrosis is the hallmark of hepatic cirrhosis, worsening of which is probably the best surrogate marker for progression of chronic liver disease,” Dr. Marc G. Ghany, of the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, and colleagues note. They used liver histology to examine the rate and predictors of fibrosis progression in 123 patients with chronic hepatitis C.
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