Increased myeloperoxidase activity and decreased antioxidant capacity appear to contribute to the pathogenesis and malignant transformation of Barrett’s esophagus, according to findings published in the December 20th issue of the International Journal of Cancer.
To examine whether oxidative stress and radical scavenger capacity play a role in the malignant transformation of Barrett’s esophagus, researchers measured myeloperoxidase activity, superoxide dismutase activity, glutathione content, and total DNA adducts from mucosal specimens taken from 52 patients with various stages of esophageal disease.
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