Combined bacterial/host genotyping appears to be useful in determining the risk of gastric carcinoma in patients with chronic gastritis, according to a report published in the November 20th issue of the Journal of the National Cancer Institute. In fact, with certain combinations, a nearly 90-fold increase in risk is observed.
Dr. Ceu Figueiredo, from Instituto de Patologia e Imunologia Molecular da Universidad do Porto in Portugal, and colleagues performed bacterial/host genotyping in 221 subjects with chronic gastritis and 222 patients with gastric carcinoma. Specifically, the researchers tested for mutations in Helicobacter pylori genes and in two host genes–interleukin (IL)-1B and IL-1 receptor antagonist (IL-1RN).
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