At the Infectious Disease Society of America (ISDA) annual meeting held in Chicago, Illinois, from Oct. 24 to 27, investigators from Israel reported on their experience with instituting hepatitis A virus (HAV) vaccination in toddlers. They found a more than 90% reduction in disease not only among the two- to four-year-olds, but in all age groups.
This finding, most likely reflecting herd immunity, suggests that catch-up vaccination is not necessary. “National anti-HAV immunization program aimed exclusively at toddlers resulted in abrupt disease reduction of >90%, not only among vaccine recipients, but also among all other age groups, by achieving high-level immunity in 2-4 year-olds, the major transmitters of HAV,” write Ron Dagan, from Ben-Gurion University in Beer-Sheva, Israel, and colleagues.
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