Superinfection from hepatitis E virus may lead to severe hepatic decompensation in adult patients with chronic liver disease. This vulnerability determines their suitability for vaccination against the infection.
The majority of adult patients in endemic areas who have chronic liver disease caused by hepatitis C have been exposed to hepatitis A virus infection. Nevertheless, they may still be vulnerable to hepatitis E virus, which could lead to an increase in morbidity and mortality. Clinicians at the Aga Khan University in Karachi, Pakistan, had already documented hepatitis E virus superinfection in four patients with chronic liver disease (CLD) which had led to severe liver decompensation.
Consequently, they designed a study to determine the seroprevalence of HAV and hepatitis E (HEV) among patients with stable CLD.
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