A bolus infusion of erythromycin made endoscopy shorter and easier in acute gastrointestinal bleeding, according to the results of a randomized, controlled, double-blind trial reported in the July issue of Gastroenterology.
“Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility,” write Jean L. Frossard and colleagues from Geneva University Hospitals in Switzerland.
“Erythromycin, a motilin agonist, induces gastric emptying.” Patients admitted within 12 hours after hematemesis were randomly assigned to receive erythromycin 250 mg or placebo 20 minutes before endoscopy. Endoscopy revealed a clear stomach in 82% of 51 patients in the erythromycin group and in 33% of 54 patients in the placebo group (P<.001). This difference remained significant even in patients with cirrhosis.
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