Laurie Barclay, MD
NEW YORK (MedscapeWire) Apr 18 Antireflux surgery for gastroesophageal reflux disease (GERD) may reduce chronic cough refractory to acid blockade, according to results of a prospective trial reported in the April issue of Chest.
"While medical therapy may fail to improve cough due to GERD, it is not known if inadequate esophageal acid suppression is responsible," write Richard S. Irwin, MD, FCCP, and colleagues from the University of Massachusetts Medical School in Worcester. "Antireflux surgery can improve chronic cough due to GERD resistant to intensive medical therapy."
In this before-and-after interventional trial, all 8 patients met a profile predicting that cough was likely due to GERD and had an initial positive 24-hour esophageal pH monitoring study. They received gradually intensified medical therapy until esophageal pH stayed above 4 and there were no acid reflux events lasting longer than 4 minutes.
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