Melatonin does not appear to be a useful therapy for patients with cluster headache who achieve incomplete relief with conventional therapy, according to a recent report by Canadian researchers.
Given the periodic nature of cluster headaches, some researchers have suggested that the condition may involve a disturbance of the suprachiasmatic nucleus of the hypothalamus, which regulates circadian rhythms. Because melatonin is known to shift circadian rhythms, it could be a useful treatment for cluster headaches.
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