The risk of subclinical coronary atherosclerosis increases with insulin resistance and increases progressively with the degree of impaired glucose tolerance, according to data from the community-based Framingham Offspring Study.
The findings lend support to the hypothesis that cardiovascular disease (CVD) and type 2 diabetes have a common etiology, according to Dr. James B. Meigs, of Massachusetts General Hospital in Boston, and colleagues.
The researchers reasoned that if type 2 diabetes and CVD have a common antecedent, subclinical atherosclerosis should be detectable not just in individuals with diagnosed diabetes, as has previously been shown, but also in those with subdiabetic glucose intolerance or insulin resistance.
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