Acute elevation of plasma free-fatty-acid concentrations in critically-ill patients requiring parenteral nutrition do not modify cardiac ventricular repolarization.
To determine whether acute elevations of plasma free fatty acid concentrations influence the corrected Q-T interval (Q-Tc), Q-Tc dispersion and sympathetic nervous system activity in patients treated with fat emulsion infusion, Dr. F Nappo of the Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, and colleagues enrolled 30 hospitalised patients with a mean age of 62 years who required parenteral nutrition.
They administered a 500 mL infusion of 10% triacylglycerol emulsion as a source of calories (450 Kcal). The same patients also received, on another occasion and in random order, a 500 mL infusion of 20% triacylglycerol emulsion (900 Kcal). The infusions lasted eight hours, and were preceded by heparin injections.
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