Increased levels of plasma homocysteine independently predict risk of congestive heart failure (CHF) in adults who have not had a prior myocardial infarction (MI), results of a study indicate. The community-based study included 2,491 adults who took part in Framingham Heart Study examinations between 1979 and 1982 and 1986 to 1990. Participants were free of CHF or prior MI at baseline.
Mean age was 72 years, and 1,547 participants were women. Plasma homocysteine levels higher than sex-specific median values were associated with an adjusted hazards ratio for heart failure of 1.93 in women and 1.84 in men, after the researchers controlled for established CHF risk factors that included prior MI. In women, elevated plasma homocysteine concentration was related positively, strongly and in continuous fashion to CHF risk, say researchers, led by Dr. Ramachandran Vasan of the US National Heart, Lung and Blood Institute’s Framingham Heart Study in Framingham, Massachusetts.
“Risk of CHF doubled at the second quartile and a four-fold risk was observed for those with values in the top quartile versus those whose values were in the lowest quartile (in women),” they explain. For men, the association became evident only at values exceeding the median….
JAMA, 2003;289:1251-1257 <!–Journal of the American Medical Association (JAMA)
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