Acetylcysteine, an antioxidant, protects against renal dysfunction in patients with chronic renal insufficiency who are undergoing coronary angiography, research from Hong Kong indicates.
The agent’s reno-protective effects are similar in patient subgroups, and there are minimal adverse effects with it, say investigators led by Dr. Jay Kay of Grantham Hospital at the University of Hong Kong. Protective effects were seen in patients undergoing coronary diagnostic and/or interventional procedures.
Similar changes seen in serum urea and creatinine concentrations suggest “the changes in glomerular filtration underlie the prophylactic effects of acetylcysteine,” the researchers add.
Two hundred patients were randomised in a prospective, double-blind trial at Grantham Hospital between May 2000 and December 2001. On the day before and on the day of angiography, 102 participants were assigned to receive 600 milligrams of oral acetylcysteine twice a day. The other 98 patients received placebo tablets.
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