Evidence that bone-marrow stem-cell transplantation could regenerate damaged cells in the heart after myocardial infarction is demonstrated by separate research among teams in Germany and China.
Dr. Gustav Steinhoff and colleagues from the department of cardiac surgery, University of Rostock, Germany, injected six patients with bone-marrow stem cells into areas of the heart which had died as a result of myocardial infarction.
These patients had also received conventional coronary artery bypass grafting (CABG). All patients were alive and well after surgery, and five of them had strikingly improved blood flow to the heart, suggesting that the stem cells may have induced angiogenesis in previously damaged areas. Dr. Steinhoff and colleagues said that while they have shown that local bone-marrow stem-cell implantation for myocardial regeneration together with CABG is safe, “whether a larger number of cells than that which we used will be tolerated is unclear.”
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