In patients with acute myocardial infarction, pretreatment with monteplase, a new thrombolytic agent that does not influence plasminogen activator inhibitor-1 (PAI-1) activity, before coronary angioplasty is a promising treatment strategy.
These are the initial results of the COMA (COmbining Monteplase with Angioplasty) Trial, reported by a Japanese team in the October issue of the American Heart Journal.
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