Growth hormone reduces serum levels of proinflammatory cytokines in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy. It also reduces soluble Fas and soluble Fas ligand system in these patients.
These immunomodulatory effects may be associated with patients’ improved clinical performance and exercise capacity, according to investigators in Athens, Greece. They noted that abnormal proinflammatory cytokine expression and apoptotic process had been shown to contribute to adverse left ventricular remodeling and progress of chronic heart failure.
This led them to study the effects of growth hormone on serum levels of representative proinflammatory cytokines and soluble apoptosis mediators in chronic heart failure secondary to idiopathic dilated cardiomyopathy.
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