In insulin-resistant, obese patients, accumulation of lipid substrates in the liver interferes with apoB clearance and may account for increased risk of cardiovascular disease. The combination of fish oil and a statin improves apoB metabolism in these patients, study findings suggest.
Dr. Gerald F. Watts and colleagues from the University of Western Australia in Crawley studied the independent and combined effects of decreasing cholesterol synthesis with atorvastatin (40 mg/day) and triglyceride synthesis with fish oil (4 g/day) in 48 viscerally obese men with insulin-resistance and dyslipidemia.
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