Diuretic resistance should be considered to be a prognostic indicator in patients with advanced chronic heart failure
This is the conclusion of a retrospective study to define the prognostic importance of diuretic resistance, as evidenced by high-dose requirement, in 1,153 patients with advanced chronic heart failure who were enrolled in the Prospective Randomized Amlodipine Survival Evaluation (PRAISE) study.
Dr. Gerald Neuberg from Columbia University, College of Physicians and Surgeons, New York, New York, and colleagues found that high diuretic doses were independently associated with mortality, sudden death, and pump failure death (adjusted hazard ratios [HRs] 1.37 [p = .004], 1.39 [p = .042], and 1.51 [p = .034], respectively).
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