Researchers working with cardiomyopathic hamsters have shown that a recombinant vector that expresses activated phospholamban improves cardiac function after injection into the animals’ right coronary artery, according to a report in the July 22nd advance online publication of Nature Medicine.
Dr. Kenneth R. Chien from the University of California at San Diego, and colleagues say that the recombinant adeno-associated virus (rAAV) and transcoronary delivery system “allows stable, high efficiency and relatively cardiac-selective gene expression.”
The rAAV was used to express a pseudophosphorylated mutant of human phospholamban, S16EPLN–designed to mimic phospholamban that has been phosphorylated by protein kinase A–which is a regulator of cardiac sarcoplasmic reticulum Ca2+ cycling.
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