Human papillomavirus (HPV) infection precedes development of cervical cancer, according to a population-based prospective study published in the Sept. 14 issue of the British Medical Journal. Most cases of HPV infection are transient, but persistent infection, particularly with the same viral type, significantly increases the risk of high-grade lesions.
“We have shown that HPV infection precedes the development of low and high grade squamous intraepithelial lesions and that high risk HPV infection is a good predictor of subsequent high grade lesions in young women,” write Susanne K. Kjaer, from the Institute of Cancer Epidemiology in Copenhagen, Denmark, and colleagues. “HPV is an even better predictor in older women with a lower background HPV prevalence.”
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