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Cytotoxicity evaluation of gutta-percha solvents: Chloroform and GP-Solvent (limonene)
La-ongthong Vajrabhaya, DDS a * [MEDLINE LOOKUP]
Suwanna K. Suwannawong, BSc b [MEDLINE LOOKUP]
Roongrawee Kamolroongwarakul, DDS c [MEDLINE LOOKUP]
Lalita Pewklieng, DDS d [MEDLINE LOOKUP]
Objective The purpose of this study was to compare the cytotoxicity of 2 gutta-percha solvents, chloroform and GP-Solvent, on cell line L929.
Study design 2 gutta-percha solvents were diluted into the concentrations of 1:100, 1:400, and 1:800. The experiment was done in a 96-well tissue-culture plate. Cell viability of L929 was determined after each gutta-percha solvent was left in contact with MTT solution for 3 hours.
Results Both solvents proved toxic at the same levels of concentrations of 1:100 and 1:400 (P>.05). At the dilution of 1:800 the GP-Solvent seems to be more toxic than the chloroform (P < .05).
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