Compared with lean subjects, obese individuals have delayed transcapillary transport of insulin to muscle tissue, Swedish researchers report in the September issue of Diabetes.
Dr. Mikaela Sjostrand of Sahlgrenska University Hospital, Goteborg, and colleagues note that insulin-resistant subjects have a slow onset of insulin action.
To determine whether delayed transcapillary action might be involved, the researchers investigated the kinetics of infused insulin and insulin in plasma and muscle interstitial fluid. A total of 10 insulin-resistant obese subjects and 10 lean controls were evaluated.
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