Oral etidronate transiently relieves metastatic bone cancer pain by decreasing abnormally elevated bone resorption.
Jun Iwamoto, from Keio University School of Medicine, in Tokyo, Japan, and colleagues studied 30 outpatients with cancer, 10 of whom had pain caused by bone metastases from the primary cancer site — four lung, three prostate and three breast.
Twenty of the other patients had primary cancer of the stomach, colon, breast, lung, or bladder, with no evidence of skeletal involvement. None of the patients with bone metastases needed morphine for pain relief or had hypercalcaemia, although all of them continued to take nonsteroidal anti-inflammatory drugs, the researchers report.
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