In a multicenter, randomized, double-blind parallel group study of patients with mild to moderate pain associated with osteoarthritis of the hip and/or knee, extended release oxymorphone, an investigational formulation of the semisynthetic opioid agonist, demonstrated superior analgesic efficacy to oxycodone CR (OxyContin®) and placebo.
The findings were presented August 21st at the 10th World Congress on Pain. In an interview, lead author Alan K. Matsumoto, MD, said the drug “may be a good therapeutic option for patients with chronic knee or hip pain, especially since opioids do not have the GI toxicity associated with NSAIDs.”
Four hundred sixty-seven patients with Kellgren-Lawrence grade II-IV osteoarthritis of the hip or knee, and index joint pain rated >40mm (VAS) and incomplete response to NSAIDs were randomized to: oxymorphone ER 40mg or 20mg every 12 hours, OxyContin 20 mg every 12 hours, or placebo. Primary outcome was change in VAS pain at week three.
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