A history of prostate cancer is an absolute medical contraindication to testosterone supplementation, according to an international consensus committee.
The guideline, issued by a subcommittee during the 3rd International Consultation on Prostate Cancer here this week, would seem to be intuitive, given that prostate cancer thrives on testosterone, and blockade with drugs or castration is standard treatment for men with advanced disease. But what about men who have been treated and are presumably cured of prostate cancer? Such men are typically older than 70 years and are often faced with hypogonadism, muscle atrophy, and declining sexual potency.
Older men are increasingly asking their physicians about testosterone supplementation, just as women for years have considered estrogen replacement therapy after menopause. There are no data showing that men with normal testosterone levels who have not had natural prostate cancer are at any higher risk for developing the disease than men with lower testosterone levels. And there are no studies in humans on testosterone supplementation after treatment for prostate cancer.
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