Men and women with established osteoporosis can be treated effectively and safely with daily pamidronate. (Aredia in Israel)
The treatment was well tolerated, found this double-blind, placebo-controlled trial by researchers at specialist centres in The Netherlands and England. Seventy eight postmenopausal women and 23 men with at least one prevalent vertebral fracture were given either pamidronate or treated with placebo. No difference in gastrointestinal toxicity was observed between the two groups. The subjects were randomised separately to the pamidronate treatment of 150 mg/day or placebo for three years, followed by a further two years of 150 mg/day of pamidronate. Every patient was also given 500 mg/day of elemental calcium and 400 U/day of cholecalciferol. Bone mineral density of the femoral neck (FN-BMD) and of the lumbar spine (LS-BMD) was found to be significantly increased by pamidronate. After five years of treatment there was a total increase of 14.3 percent in BMD.
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