05/22/2002 By James Adams
Amylin, a peptide hormone co-secreted with insulin by pancreatic ß cells, appears to play a role in the regulation of blood glucose levels in response to exercise.
Previous studies have reported that amylin inhibits release of postprandial glucagon and insulin and modulates gastric emptying.
As changes in glucagon and insulin are also important for controlling blood glucose in response to situations that elevate metabolic rate, investigators hypothesized that amylin may be involved in regulating blood glucose in response to exercise.
The investigators, from multiple institutions including Southeastern Louisiana University in Hammond, Louisiana, and Amylin Pharmaceuticals in San Diego, California, United States, studied seven well-trained male subjects who completed an intermittent exercise program on a treadmill at progressive intensities of 60, 75, 90 and 100 percent maximum oxygen consumption.
Blood samples were obtained before exercise, after each progression of intensity and one hour following exercise. A control trial was also conducted without exercise.
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