e-med-isral-ribbon

Nimesulide more cost-effective than diclofenac for osteoarthritis

המידע באדיבות medicontext.co.il
Last Updated: 2001-08-21 9:35:41 EDT (Reuters Health)

LONDON (Reuters Health) – The nonsteroidal anti-inflammatory drug nimesulide is more cost-effective than diclofenac for the treatment of osteoarthritis, according to an analysis of epidemiologic data from France, Italy and Spain.

Dr. Rosanna Tarricone from Bocconi University, in Milan, and colleagues determined the incidence of gastrointestinal adverse events during treatment with nimesulide and diclofenac by performing a meta-analysis of three studies that compared the drugs in a total of 484 patients. They then constructed a decision tree to perform a cost-minimisation analysis of data from the National Health Service (NHS) of the three countries.

Meta-analysis confirmed that the incidence of gastrointestinal adverse events was higher in patients receiving diclofenac than in those receiving nimesulide, the researchers report in the July issue of Clinical Drug Investigations. The meta-analysis provided incidence rates for the occurrence of adverse events that the researchers used to calculate probability values for the decision tree.

Taking into account the cost of 15 days of treatment with nimesulide or diclofenac and the costs of treating gastrointestinal adverse events, the expected per-case cost of treatment with nimesulide was about EUR7 in France, EUR10 in Italy and EUR17 in Spain. For diclofenac, the costs were EUR8 in France, EUR12 in Italy and EUR21 in Spain, Dr. Tarricone's group estimated.

Treatment with nimesulide resulted in a cost savings, per case, of EUR1.5 in France, EUR2 in Italy and EUR3.6 in Spain. "By projecting these results to the estimated osteoarthritis prevalence in the entire population residing in the three countries, expected savings to the NHS would vary from a minimum of EUR17,500,000 in France to a maximum of EUR30,000,000 in Spain," Dr. Tarricone and colleagues conclude.

Clin Drug Invest 2001;21:453-464.

-London Newsroom +44 20 7542 7986

0 תגובות

השאירו תגובה

רוצה להצטרף לדיון?
תרגישו חופשי לתרום!

כתיבת תגובה

מידע נוסף לעיונך

כתבות בנושאים דומים

© ‫ אי-מד שיווק רפואי בע”מ
 כל הזכויות שמורות
09-765-8233 

 

הנך גולש/ת באתר כאורח/ת.

במידה והנך מנוי את/ה מוזמן/ת לבצע כניסה מזוהה וליהנות מגישה לכל התכנים המיועדים למנויים
עדיין לא מנוי/ה ונמנה/ת על הצוות הרפואי? מוזמן/ת לבצע הרשמה כאן
להרשמה לאתר
להמשך גלישה כאורח סגור חלון זה