Seminal plasma should be measured for lead included as part of infertility evaluation among couples with unexplained fertility problems, American investigators say.
The possibility of unexpected lead damage was found by Dr Susan Benoff and colleagues at North Shore-Long Island Jewish Research Institute in Manhasset, New York, and collaborating clinicians at the Robert Wood Johnson Medical School, Camden, New Jersey and at Rochester and Cornell Universities in New York.
The investigators said that recent reports of a decline in sperm concentration and male fertility, have renewed interest in environmental exposures, particularly lead.
They found that lead levels in seminal plasma varied over a wide range and there was a significant association between high lead levels and low fertilisation rates. The changes in lead levels accounted for a fifth of the variance in fertilisation rates.



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