Patients with congestive heart failure combined with asthma tolerate carvedilol poorly, indicating that asthma is a contraindication to beta-blockade.
In contrast, patients with congestive heart failure and chronic obstructive pulmonary disease tolerate carvedilol well with no significant reversible airflow limitations. These were the findings of Dr E Kotlyar and colleagues of the cardiopulmonary Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, Australia. The researchers enrolled 487 patients to receive open-label carvedilol. Thirty one patients had COPD and 12 had asthma.
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